Extinction catastrophe of antiviral drugs Molnipiravir ( MK-4482)
Extinction catastrophe of antiviral drugs Molnipiravir ( MK-4482), Remdesivir and 4 -fluor uridine (4FIU) acting as a nucleoside analogues against pandemic human coronaviruses. Juan Carlos López Corbalán, Francisco Marco del Castillo and José Miguel Seguí Ripoll Extinction catastrophe can be experimentally induced by promutagenic nucleosides in cell culture models. The loss of HIV infectivity has been observed after passage in 5-hydroxydeoxycytidine or 5,6-dihydro-5-aza-20-deoxycytidine while producing a two-fold increase in the viral mutation frequency. Among approved nucleoside analogs, experiments with polioviruses and other RNA viruses suggested that ribavirin can be mutagenic, although its mechanism of action is not clear. Favipiravir and molnupiravir exert an antiviral effect through lethal mutagenesis. Both drugs are broad-spectrum antiviral agents active against RNA viruses. Favipiravir incorporates into viral RNA, affecting the G→A and C→U transition rates. Mol